With backbreaking work in a ramshackle lab in Paris, Marie Curie and her husband Pierre achieve a revolutionary understanding of radiation and share a Nobel Prize. When her beloved Pierre dies in an accident, Marie is plunged into depression. Paul Langevin, fleeing an unhappy marriage, gives her the strength to return to her work. But the scandal over their affair threatens to end her career - just when she might become the first person ever to receive a second Nobel Prize.